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Pentameric nCRP and CRP peptides 77–82, 174–185, and 201–206 can control the inflammatory response resolving inflammation by reducing inflammatory cell endothelial adhesion and tissue migration, and the described CRP-mediated enhanced monocyte chemotaxis could be explained by local generation of mCRP (190, 191)

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[1] These mechanisms lead to reduced caloric intake and significant weight loss, with clinical trials demonstrating average weight reductions of 15-21% over 72 weeks in the SURMOUNT-1 trial